26 days old

Postdoctoral Scientist Formulations-FDE

Cambridge, MA 02139
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Postdoctoral Scientist Formulations-FDE
United States
North America
For more than 140 years, Lilly has been dedicated to meeting the health care needs of people in the United States and around the world. We address these needs primarily by developing innovative medicines—investing a higher percentage of our sales in research and development than any other major pharmaceutical company.

In 2015, Lilly opened a state of the art Innovation Center in Cambridge, Massachusetts to explore how next generation therapeutics, connected delivery solutions, and data analytics can improve patient health while reducing the clinical, psychosocial and economic burden that is systemic throughout healthcare today. Integration of Pharmaceutical Sciences and Delivery Device Innovation is a focal point of the site. Formulation scientists and device engineers collaborate to bring innovative and integrated solutions to drug product development and delivery challenges.

We are seeking highly motivated professionals with a start-up mentality to join our new Innovation Center in Cambridge, Massachusetts, to explore, develop and prototype new and emerging formulation and drug delivery technologies. If you have an interest in exploring new frontiers in formulation and drug delivery and use interdisciplinary problem solving methods to create breakthrough solutions for patients, you should consider joining our diverse team.

The primary responsibility for the scientist will be to conduct fundamental studies to understand protein interactions at high concentrations with novel excipients. You will be responsible for conducting studies to identify excipients that can mitigate issues with high viscosity and stability. You will explore other novel and innovative ways to reduce viscosity of high concentration biologics. Understanding of physical and chemical stability challenges in high concentration bioproduct formulations will be a critical area of focus.

The responsibilities for this role will include:
  • Explore novel avenues to reduce viscosity of high concentration biologics
  • Explore interactions between excipients and proteins that can lead to reduction in viscosity and increase in stability
  • Identify and/or synthesize model excipients that can be designed to disrupt high viscosity and other challenges at high concentration
  • Based on knowledge gained, build model(s) that can predict viscosity of bioproducts using inputs such as molecule properties, surface charge and formulation variables.
  • Understand the reasons for physical and chemical stability challenges for bioproducts at high concentration
  • Keep abreast of relevant new technologies / capabilities and regulatory initiatives / requirements.
  • Authoring of technical reports, research grants, and journal publications.
  • PhD in Pharmaceutical Chemistry, Physical chemistry, Pharmaceutical Sciences, Biophysics, Biomedical Engineering or Biochemistry
  • Experience/ knowledge of biophysical, physical and chemical characterization of proteins
  • Basic understanding of insulins, peptides, proteins, degradation pathways, and general approaches for stabilization
  • Able to independently contribute from the bench (design and execute studies to develop a formulation)
  • Experience/ knowledge of parenteral formulations development for preclinical, clinical and commercial use (including lyophilized and solutions formulations).
  • In depth understanding of protein chemistry, structure and conformation, as relates to chemical and physical stability of small and large molecules.
  • Demonstrated technical / scientific leadership skills; applied to problem-solving
  • Good oral and written communication skills
  • Must be able to work productively in an interdisciplinary team environment
Lilly credits its exceptional employees for its successes, and knows the key to ongoing achievement lies in attracting and retaining the best people. A company rich in heritage, Lilly employs individuals, conducts research and markets products worldwide. By providing for the unmet needs of our customers through a continuous stream of innovation, we will outgrow all competitors.

Lilly earns consistent and wide recognition for creating an exceptional work environment:
  • Business Week magazine 50 Best Places To Launch A Careerâ„¢
  • FORTUNE America’s Most Admired Companiesâ„¢
  • FORTUNE 50 Best Companies for Minoritiesâ„¢
  • Working Mother 100 Best Companies for Working Mothersâ„¢
  • Industry Week magazine 100 Best-Managed Companiesâ„¢
  • Business Ethics magazine 100 Best Corporate Citizensâ„¢
  • Science magazine Best Companies for Scientistsâ„¢
This position is not permanent. It is for a fixed duration of two years with potential to extend annually for up to 4 years.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status
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Posted: 2019-01-22 Expires: 2019-02-22

As one of the oldest continuously operating companies in the United States, we are proud of all the innovative work we’ve accomplished for the last 140 years to improve global health.

We are looking forward to an even more successful future in which continued innovation and contributions from top talent in all areas of our organization will be critical.

Are you looking for a way to make life better for people around the world? We have opportunities in many areas of our organization. Please use the search feature to see the wide scope of our positions.

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Postdoctoral Scientist Formulations-FDE

Cambridge, MA 02139
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